Design, Synthesis, Biological Evaluation and <i>In-silico</i> Docking Studies of Some Novel Imidazolone Derivatives As Potent Antimicrobial Containing Fluorine Agents

Imidazolones are potent for their intense antimicrobial and mitigating exercises wherein, an assortment of imidazolone analogs 4-aryl-1-(4-chloro-3-fluorophenyl)-2-phenyl-1H-imidazol-5(4H)-ones (2a-o) 4-aryl-2-phenyl-1-(4-(trifluoromethyl) phenyl)-1H-imidazol-5(4H)-ones (3a-o) were studied amalgamating them by using oxazolones various aryl amines. Newly synthesized compounds screened in vitro activity towards bacterial as well fungal pathogenic microscopic organisms. Among the derivatives, compound 2f, 2g, 2i, 3b, 3h, 3k showed moderate antibacterial action while 2d, 2j, 2m, 2n, 3e, 3g, 3f furnished earmarked antifungal action. In-silico docking all structures was performed targets. Out novel imidazolones, 2e, 2o 3o exhibited superior affinity against target 14?-demethylase when compared with other compounds.